Investigation of Anticancer Properties of Aloe Vera (Aloe), Coccinia grandis (Ivy Gourd), Vernonia cinerea (Little Ironweed), on Dld-1 Colon Carcinoma in Vitro
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Date
2014
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Uva Wellassa University of Sri Lanka
Abstract
Plant derived components have attracted attention as an alternative source to battle several diseases including cancer. Traditional medicine in Sri Lanka is one of the major treatment systems for many diseases followed by our ancestors. In this study, in vitro anticancer properties of Coccinia grandis, Vernonia cinerea, and Aloe vera plants on DLD-1 cancer cell line were investigated. The study was conducted to determine the anticancer properties of Aloe vera, Coccinia grandis and Vernonia cinerea plants on colon cancer cells in vitro. The crude plant leaf extracts of three plants were tested for their cytotoxicity on Vero-76 normal epithelial cell line and DLD-1 human colorectal adenocarcinoma cell line. The cytotoxicity was evaluated by performing MTT assay. In the present study, toxic effect of crude extracts was identified using Vero-76 normal cell line and anticancer properties were identified using DLD-1 cancer cell line. Out of three plant extracts tested, only Vernonia cinerea crude extract has a significant anticancer property on DLD-1 carcinoma (P<0.05). Therefore, Vernonia cinerea crude extract was identified as a source of having anticancer property on DLD-1 colon cancer cell line.
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Animal Science Degree Programme (ANS)