Vinoma, D. A. I.Niroma, D. A. O.Herath, H.M.I.U.2021-02-192021-02-1920209789550481293http://www.erepo.lib.uwu.ac.lk/bitstream/handle/123456789/6066/proceeding_oct_08-423.pdf?sequence=1&isAllowed=yLysergic corrosive diethylamide (LSD) was concentrated between the 1950s and 1970s to assess social and character changes, just as reduction of mental side effects in different disarranges. LSD was utilized in the treatment of anxiety, depression, psychosomatic diseases, and addiction. LSD perpetually includes a perplexing association between drug dosage, set, and setting. Impacts regularly incorporate changed musings, sentiments, and consciousness of one's environmental factors. A final choice of 10 articles was made after considering incorporation and prohibition standards through utilizing the PRISMA stream graph. PubMed database was looked at. Moreover, the Multidisciplinary Association for Psychedelic Studies Psychedelic Bibliography was likewise counseled. The objective of this review was to distinguish controlled and randomized clinical preliminaries that evaluate the expected utilization of LSD in psychiatry. To guarantee writing immersion, the electronic search was enhanced by literature reviews of eligible publications. Impacts ordinarily start inside thirty minutes and can keep going for as long as 12 hours. It is utilized mostly as a recreational medication or for profound reasons. Findings described significant and positive short-term changes in patients, even though in some studies an important homogenization was observed between the LSD treatment group and the control group at long-term follow-up. Therapeutic changes are maintained for 6-12 months after therapy. As a conclusion of this research suggests using LSD under the guidance of psychiatrists with the sufficient relaxation of law for the persons who need temporary mental changes such as people who perceived to suicide and suffer from depression and this drug should allow from the law only to the health care field for mental therapies. Recommend for a further researched to improve the physical effect of the LSD drug-using though it uses to the metal cure. Keywords: Psychedelic Drugs, LSD, Addiction, Hallucinogen, DepressionenHealth ScienceMedicineSocial SciencePsychologicalOther