Screening of Wood-Decaying Fungi for Antibacterial Activity Against Antibiotic Resistant Bacteria
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Date
2012
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Uva Wellassa University of Sri Lanka
Abstract
Over the last decade it has become clear that antimicrobial drugs are losing their effectiveness the due to the evolution of pathogen resistance. Therefore, there is a critical need to search new chemical compounds that can be successfully replaced as alternatives for the antibiotics in present market. Natural products are the fundamental sources of new chemical components in the pharmaceutical industry as well as auruvedic medicine. The chemical compounds derived from the natural products are less toxic and more effective than the artificial ones. Hence, the investigation of natural products that have antibiotic properties is a promising way of receiving less toxic and effective antibiotics for the consumers. Researchers are largely deal with the medicinal plants for the investigation of new drugs. But most of them are neglecting the other natural recourses such as fungus that are having great medicinal values.
Hence, the aim of this review is to explore locally available fungus varieties which are having the antibacterial properties against the highly resistant bacteria. Eight species of wood rot macrofungi were randomly collected and identified as Pleurotus pulmonarius, Pleurotus ostreatus, Tremets versicolour, Polyporus arcularius, Pluteus cervinus, Schizophyllum commune, Auricularia polytricha by using their characteristics of fruiting bodies. One fungus variety was not identify up to generic level. Ethanolic extractions of all the fungus varieties are tested against Escharichia coli, Psudomonas auriginosa and Streptococcus aurius by using disk diffusion method. It was followed by evaluation of the minimum inhibitory concentration (MIC).Ethanolic extracts of Pleurotus pulmonarius, Polyporus arcularius, Pleurotus ostreatus and Auricularia polytricha showed inhibition against all three test microorganisms. Tremets versicolour was found to be only active against Staphylococcus aureus and Psudomonas auriginosa while Schizophyllum commune only active against Escharichia coli and Streptococcus aurius. The poorest antimicrobial activity was recorded from the ethanolic extracts of Polyporus arcularius and Pleurotus ostreatus. Minimum MIC value was 8mg/m1 for tested bacteria.
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Science and Technology Degree Programme